ICU sedation, delirium & recovery
Effects of a Combined Lifestyle Intervention on Recovery of ICU Survivors: A Randomized Controlled Trial
Authors' conclusion
The data of this small-sample size randomized controlled trial suggest that a combined lifestyle intervention program can significantly improve PF and protein intake in ICU survivors with a prolonged PF scores below reference.
Study context
- Population
- Adult long-stay ICU survivors (≥ 48 hr) with physical functioning (PF) score <67% on the Dutch RAND-36, teaching hospital in the Netherlands39 completed
- Participants
- 19 vs 20
- Comparison
- Combined lifestyle intervention vs standard aftercare
- Interventionn = 19
- Controln = 20reference
- Primary endpoint
- PF score
- Follow-up
- 12 wk
Methodological detailssingle-centre, Imbalances in ICU characteristics; baseline characteristics and PF scores similar
- Single-centre
- Imbalances in ICU characteristics; baseline characteristics and PF scores similar
Primary result
As reported in the abstract
PF-domain score · 12 weeks
- Significant improvement in PF-domain score in the intervention group
- p = 0.024
Secondary outcomes
Daily protein intake, intervention group (baseline to 12 wk) · 12 weeks
- Increased from 82.3 (67.5-97.9) to 116.7 (107.3-138.7) g/kg
- P = 0.003
- Meeting minimal intake target of 1.2 g/kg/d
- 68%
Original publication
Effects of a Combined Lifestyle Intervention on Recovery of ICU Survivors: A Randomized Controlled Trial. Crit Care Med. Published 16 March 2026. doi:10.
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