Empirical antifungal therapy for health care-associated intra-abdominal infection: a retrospective, multicentre and comparative study
Authors' conclusion
The use of early empirical antifungal therapy was associated with a decreased death rate at 90 days, with no effect on the death rate at 1 year, the death rate at 30 days, the rate of re-intervention, the need for drainage, and empirical antibiotic and antifungal therapy failure at 30 days.
Study context
- Population
- Intensive care unit (ICU) adults requiring re-intervention after abdominal surgery with health care-associated intra-abdominal infection (HC-IAI), 3 ICUs in France
- Exposure
- Early empirical antifungals vs no antifungals
- Outcome
- Death rate
- Follow-up
- 90 days
Methodological detailsmulticentre, overlap propensity score weighting
- Multicentre
- Overlap propensity score weighting
Main finding
As reported in the abstract
P = 0.02
Observational data: associations, not effects.
Secondary outcomes
Death rate at 1 y; 30-day composite (re-intervention, inappropriate antimicrobial therapy, death)
- No differences for the secondary outcomes
Original publication
Empirical antifungal therapy for health care-associated intra-abdominal infection: a retrospective, multicentre and comparative study. Ann Intensive Care. Published 25 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →