Epidemiology and Clinical Patterns of Lung Abscesses in ICU: A French Multicenter Retrospective Study
Authors' conclusion
Pulmonary abscesses in the ICU are a rare but severe disease often resulting from a polymicrobial infection, with a high proportion of Enterobacteriaceae, S aureus, and P aeruginosa. Percutaneous drainage, surgery, or arterial embolization was required in more than one-third of cases.
Study context
- Population
- Critically ill ICU patients with lung abscesses, France, 2015–2022
- Participants
- 171 patients
- Outcome
- In-ICU mortality and its risk factors
Methodological detailsmulticentre, ICD-10 code based, multivariate logistic regression
- Multicentre
- ICD-10 code based
- Multivariate logistic regression
Main finding
As reported in the abstract
In-ICU mortality and independent predictors
In-ICU mortality
21.5%
Age, OR [1.02-1.91], P = .007
1.05
RRT during ICU stay, OR [1.24-10.57], P = .019
3.56
Fungal infection, OR [2.69-34.5], P = .0006
9.12
Observational data: associations, not effects.
Further findings
Patient characteristics
- Male
- 78%
- Mean age (± SD), years
- 56.5 ± 16.4
- Alcohol misuse
- 20.4%
- Chronic lung disease
- 25.2%
- COPD
- 14%
- History of cancer
- 20.5%
- Immunocompromised
- 40.9%
- Nosocomial infection
- 38%
Presenting symptoms
- Fatigue or weight loss
- 62%
- Fever
- 50.3%
- Dyspnea
- 47.4%
- Hemoptysis
- 21.7%
Microbiology
- Polymicrobial infection
- 35.6%
- Enterobacteriaceae
- 31%
- Staphylococcus aureus
- 22%
- Pseudomonas aeruginosa
- 19.3%
- Fungal infections
- 10.5%
- Clusters of clinicoradiologic patterns associated with specific microbiological documentation
Management
- Percutaneous abscess drainage
- 11.7%
- Surgery
- 12.7%
- Bronchial artery embolization for hemoptysis
- 12%
Original publication
Epidemiology and Clinical Patterns of Lung Abscesses in ICU: A French Multicenter Retrospective Study. Chest. Published 29 August 2023. doi:10.
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