Perioperative medicine & outcomes
Epidemiology of perioperative anaphylaxis in France in 2017–2018: the 11th GERAP survey
Authors' conclusion
Our results confirm that most commonly identified triggering agents remain neuromuscular blocking agents. Reactions to antibiotics, particularly cefazolin, are becoming increasingly frequent.
Study context
- Population
- Patients with perioperative anaphylaxis in 26 allergy clinics of the GERAP network, France, 2017–8
- Participants
- 765 patients · 26 allergy clinics
- Outcome
- Culprit agents of perioperative anaphylaxis
Main finding
As reported in the abstract
- Severe reactions (Ring and Messmer grade 3 or 4)
- 428 (56%)
- Culprit agent identified (of 676 with skin tests)
- 471 (70%)
- NMBAs as cause
- n=281; 60%
- Antibiotics as cause
- n=118; 25%
- Patent blue dye as cause
- n=11; 2%
- Cefazolin, share of antibiotic-related reactions
- 52%
- Suxamethonium, reactions per 100,000 vials sold
- 7.1 (6.1-8.4)
- Rocuronium, reactions per 100,000 vials sold
- 5.6 (4.2-7.4)
- Cefazolin, reactions per 100,000 vials sold
- 0.7 (0.5-0.9)
Observational data: associations, not effects.
Original publication
Epidemiology of perioperative anaphylaxis in France in 2017–2018: the 11th GERAP survey. Br J Anaesth. Published 16 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →