Perioperative medicine & outcomes
Epidemiology and Triggers of Severe Perioperative Anaphylaxis: An 8-Year Single-Center Study
Authors' conclusion
Perioperative severe anaphylaxis is a rare but life-threatening complication. Previous allergic history, cisatracurium, hydroxyethyl starch 130/0.4, and allogeneic plasma may be the independent triggers.
Study context
- Population
- All patients undergoing surgery and anesthesia in the OR, tertiary hospital in China, January 2014 to February 2022
- Participants
- 266,033 surgeries
- Comparison
- Severe perioperative anaphylaxis cases vs matched controls
- Casesn = 97
- Outcome
- Incidence and independent triggers of severe perioperative anaphylaxis
Methodological detailssingle-centre, controls matched 4:1 on same operation day
- Single-centre
- Controls matched 4:1 on same operation day
Main finding
As reported in the abstract
Cases
3.6 per 10,000
97 of 97
Odds ratio (95% CI)P value
Allergy history
5.23(2.35–11.68)
P < 0.001Cisatracurium use
5.03(1.22–20.70)
P < 0.001Hydroxyethyl starch 130/0.4 use
5.36(2.99–9.60)
P = 0.025Allogeneic plasma
11.02(3.78–35.95)
P < 0.001Observational data: associations, not effects.
Further findings
- Severe allergic reaction again during second surgery — Cases
- 3 events
- Severe allergic reaction again during second surgery: 3 of 97
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Epidemiology and Triggers of Severe Perioperative Anaphylaxis: An 8-Year Single-Center Study. J Cardiothorac Vasc Anesth. Published 26 June 2024. doi:10.
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