Epidemiology of sepsis-associated acute kidney injury in the intensive care units (ICU) with contemporary consensus definitions
Authors' conclusion
Applying updated consensus definitions highlights the high prevalence of SA-AKI in the ICU and its significant associated morbidity and mortality.
Study context
- Population
- Adults admitted to ICU, 2010–2022
- Participants
- 187,888 adults
- Exposure
- Sepsis-associated acute kidney injury (SA-AKI) vs sepsis alone or AKI alone
- Outcome
- Hospital mortality and major adverse kidney events (MAKE = death, kidney replacement therapy, or reduced kidney function from baseline)
- Follow-up
- Discharge
Methodological detailstwo academic medical centres
- Two academic medical centres
Main finding
As reported in the abstract
SA-AKI vs Sepsis alone or AKI aloneEstimate (95% CI)
Mortality
aHR 1.59(1.51–1.66)
MAKE
aOR 3.35(3.19–3.51)
- Hospital death among SA-AKI
- 1 in 4
- At least one MAKE by discharge among SA-AKI
- 37.7%
Observational data: associations, not effects.
Further findings
SA-AKI phenotypes (timing of onset, septic shock)
- Early phenotype most common; incident AKI decreasing daily from sepsis onset
- Septic shock significantly worsened outcomes
Original publication
Epidemiology of sepsis-associated acute kidney injury in the ICU with contemporary consensus definitions. Crit Care. Published 20 March 2025. doi:10.
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