Erector spinae plane block versus paravertebral block and placebo for recovery quality after percutaneous nephrolithotomy: A randomized controlled trial
Authors' conclusion
ESPB significantly improved recovery quality after PCNL, demonstrating superiority to placebo and non-inferiority to TPVB.
Study context
- Population
- Adults, ASA I–II, scheduled for elective unilateral PCNL, Sanming First Hospital, Chinarandomized 1:1:1
- Participants
- 120 adults
- Comparison
- ESPB vs TPVB vs placebo
- Primary endpoint
- QoR-15 score
- Follow-up
- 24 h
Methodological detailsdouble-blind, placebo-controlled, non-inferiority, single-centre
- Double-blind
- Placebo-controlled
- Non-inferiority
- Single-centre
Primary result
As reported in the abstract
Median difference, points (95% CI)P value
ESPB vs Placebosuperiority
11.0(7.0–14.0)
P < 0.001Median difference, point (95% CI)
ESPB vs TPVBmet non-inferiority criteria (6-point margin)
1.0(−5.0 to 2.0)
Secondary outcomes
Pain scores and morphine consumption
- Both blocks reduced pain scores and morphine consumption by ≈40% vs placebo, no differences between techniques
- P < 0.001
Time to first rescue analgesia
- Prolonged with both blocks vs placebo
- P < 0.001
Patient satisfaction
- Higher with both blocks than with placebo
- P < 0.001
Safety
- No block-related complications occurred
- Postoperative adverse events similar across groups
Original publication
Erector spinae plane block versus paravertebral block and placebo for recovery quality after percutaneous nephrolithotomy: A randomized controlled trial. J Clin Anesth. Published 5 November 2025. doi:10.
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