Erythropoietin as a critical prognostic indicator in ICU patients with sepsis: a prospective observational study
Main finding · 28-day mortalityResult — go to the resultHazard ratio 2.93 95% CI 1.20–7.22Authors' conclusion
Elevated EPO levels in patients with sepsis are correlated with unfavorable prognoses and may function as a prognostic biomarker for adverse outcomes.
Study context
- Population
- ICU patients with sepsis65.17% male
- Participants
- 267 patients
- Exposure
- Highest vs lowest erythropoietin (EPO) tertile
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Main finding
As reported in the abstract
Hazard ratio
2.93
95% CI 1.20–7.22
Highest EPO tertile vs Lowest EPO tertile
HR 2.93 (95% CI 1.20–7.22)
- Overall 28-day mortality rate
- 23.22%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Hospital mortalityHighest EPO tertile vs Lowest EPO tertile · multivariate Cox regression | 2.47 (1.05–5.81) | |
| 0.20.5125Hazard ratio (log scale) |
- Hospital mortality — Overall hospital mortality rate
- 31.20%
28-day mortality (subgroups)
- Consistent effect size and direction across subgroups
Mediation of lactate–28-day mortality association by EPO
- Partially mediated by EPO; mediation ratio
- 12.59%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Erythropoietin as a critical prognostic indicator in ICU patients with sepsis: a prospective observational study. J Intensive Care. Published 20 March 2025. doi:10.
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