Esketamine: Less Drowsiness, More Analgesia

Anesth AnalgPublished 31 Jan 2024Narrative review

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Study context

Population: Anesthesia literature on mental, cardiovascular, cerebral and antinociceptive effects of esketamine, published in English 1980–2022

Comparison: Esketamine vs racemic ketamine
Outcome: Mental, cardiovascular, cerebral and antinociceptive effects of esketamine vs racemic ketamine and placebo

As reported in the abstract

Dose reduction in anesthesia and analgesia with esketamine, with higher clearance and shorter recovery time vs racemic ketamine

≈50%

Esketamine vs racemic ketamine (and vs placebo)

Esketamine and racemic ketamine not "the same" at clinically equivalent analgesic and anesthetic dose
Esketamine not devoid of unwanted mental impact; probably less cholinergic inhibition

More notes

Cognitive disturbances during arousal, awakening and recovery less, and less pronounced with esketamine
Esketamine vs placebo: cardiocirculatory stabilizing and neuroprotective effects
Evidence of antinociceptive efficacy inconsistent

Esketamine: Less Drowsiness, More Analgesia. Anesth Analg. Published 31 January 2024. doi:10.1213/ane.0000000000006851

Composed by AI from the published abstract and checked against it. How Briefs are made →