ICU sedation, delirium & recovery
Estimated glomerular filtration rate among intensive care unit survivors: From the removal of race coefficient to cystatin C-based equations
Authors' conclusion
Among ICU survivors, removal of race coefficient leads to lower eGFR in Black patients and may contribute to overestimation of kidney function in non-Black patients. While cysC is rarely used, estimates based on this marker are significantly lower than those based on sCr.
Study context
- Population
- Intensive care unit (ICU) survivors from 2 institutions in the Bronx and Boston; Estimated glomerular filtration rate (eGFR) at hospital discharge
- Participants
- 30,920 survivors
- Exposure
- eGFR with vs without race coefficient; Cystatin C (cysC)- vs serum creatinine (sCr)-based eGFR
- Outcome
- eGFRsCr2021 vs eGFRsCr2009
- Follow-up
- Hospital discharge
Methodological detailstwo-centre
- Two-centre
Main finding
As reported in the abstract
Median difference
4 ml/min/1.73 m²
higher among non-Black patients
Median difference
8 ml/min/1.73 m²
lower among Black patients
- Non-Black subjects reclassified to better eGFR category
- 12.9%
- Black subjects reclassified to worse eGFR category
- 16.1%
Observational data: associations, not effects.
Further findings
| Outcome | Median difference (ml/min/1.73 m²) |
|---|---|
| cysC- vs sCr-based eGFR (subset with available cysC: 51 patients, 108 measurements) · between ICU admission and 1-year follow-upcysC-based estimates lower | 9 to 16 |
- cysC- vs sCr-based eGFR (subset with available cysC: 51 patients, 108 measurements) — Measurements reclassified to worse eGFR category
- 34% to 53.5%
Original publication
Estimated glomerular filtration rate among intensive care unit survivors: From the removal of race coefficient to cystatin C-based equations. J Crit Care. Published 31 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →