Hemodynamics, fluids & transfusion
Evaluating Topical Antifibrinolytics in Cardiac Surgery: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis
Pooled result · Postoperative blood lossResult — go to the resultMD −173.99 mL 95% CI −238.20 to −109.78Authors' conclusion
Topical LAAF administration reduces postoperative blood loss up to 24 hours postoperatively. Secondary analyses showed reductions in PRBC transfusion volume and fresh frozen plasma transfusion rate, without increased complications.
Study context
- Population
- Patients undergoing cardiac surgery
- Participants
- 2,624 patients · 26 studies
- Comparison
- Topical lysine analog antifibrinolytics vs placebo
- Outcome
- Postoperative blood loss
- Follow-up
- Up to 24 hours postoperatively
Methodological detailsrandom-effects model, trial sequential analysis, GRADE
- Random-effects model
- Trial sequential analysis
- GRADE
Pooled result
As reported in the abstract
MD
−173.99 mL
95% CI −238.20 to −109.78
P < 0.00001
LAAF vs Placebo
MD −173.99 mL (95% CI −238.20 to −109.78); P < 0.00001
Further pooled results
| Outcome | MD (units) (95% CI) | P value | |
|---|---|---|---|
| PRBC volume | −0.6 (−0.88 to −0.24) | P = 0.00006 | |
| −1−0.500.5Difference, units (linear scale) |
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Fresh frozen plasma requirements | 0.69 (0.5–0.95) | P = 0.03 | |
| 0.512Relative risk (log scale) |
Transfusion rates for packed red blood cells (PRBC) and platelets
- No significant differences
Hematological change scores
- No differences observed
Safety
Complication rates
- No differences observed
Original publication
Evaluating Topical Antifibrinolytics in Cardiac Surgery: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis. J Cardiothorac Vasc Anesth. Published 30 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →