Pediatric anesthesia & critical care
Evaluation of Intraoperative Bivalirudin Anticoagulation in Neonates and Infants Undergoing Arterial Switch Operation on Integrated ECMO-CPB Circuit: A Prospective Study
Authors' conclusion
Bivalirudin can be effectively used for anticoagulation during CPB in neonates and infants with transposition of great arteries, at a bolus dose of 1 mg/kg and a maintenance dose of 2.1 ± 0.3 mg/kg/h, utilizing the integrated extracorporeal membrane oxygenation-CPB circuit.
Study context
- Population
- Neonates and infants with transposition of great arteries undergoing arterial switch operation on integrated ECMO-CPB circuit, tertiary care hospital
- Participants
- 10 neonates
- Outcome
- Bivalirudin dose required
Methodological detailsprospective, single-group
- Prospective
- Single-group
Main finding
As reported in the abstract
| Group | Value | Bolus dose required | Children requiring additional 0.5 mg/kg bolus |
|---|---|---|---|
| Bivalirudin | 2.1 ± 0.3 mg/kg/h | 1 mg/kg | 2 |
Bivalirudin
Value2.1 ± 0.3 mg/kg/h
Bolus dose required1 mg/kg
Children requiring additional 0.5 mg/kg bolus2
Observational data: associations, not effects.
Further findings
Activated clotting time (ACT)
- Mean baseline ACT, s
- 207.6 ± 52.4
- Mean ACT of priming solution, s
- 999
- Mean ACT after bolus, s
- 575.9 ± 101
- Mean ACT on CPB after 30 min, s
- 956.2 ± 62.8
- Mean ACT on CPB after 60 min, s
- 936.8 ± 137
- Mean ACT on CPB after 90 min, s
- 829.6 ± 232.5
Bivalirudin dose required
- Bolus dose required, mg/kg
- 1
- Children requiring additional 0.5 mg/kg bolus
- 2
- Maintenance dose required, mg/kg/h
- 2.1 ± 0.3
Safety
- No clot formation in the circuit or thromboembolic complications
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Evaluation of Intraoperative Bivalirudin Anticoagulation in Neonates and Infants Undergoing Arterial Switch Operation on Integrated ECMO-CPB Circuit: A Prospective Study. J Cardiothorac Vasc Anesth. Published 29 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →