Pediatric anesthesia & critical care
Spontaneous recovery from neuromuscular block after a single dose of a muscle relaxant in pediatric patients: A systematic review using a network meta‐analytic and meta‐regression approach
Authors' conclusion
The times to neuromuscular recovery are highly variable. These can decrease significantly with age and are prolonged when volatile anesthetics are administered.
Study context
- Population
- Healthy pediatric participants receiving a single bolus of a common NMBA71 randomized controlled trials (RCTs)/controlled clinical trials (CCTs)
- Participants
- 4,319 participants
- Comparison
- Single-bolus NMBA treatments and age groups
- Outcome
- Spontaneous recovery: time to 25% T1 (t25), from 25% to 75% T1 (RI25-75), and to ≥90% TOF (tTOF90)
Methodological detailsBayesian random-effects network and pairwise meta-analyses, meta-regression
- Bayesian random-effects network and pairwise meta-analyses
- Meta-regression
Pooled result
As reported in the abstract
tTOF90
Mean difference (shorter in children), min (CrI95 CI)
Children vs Neonates
41.96(14.35–69.50)
Children vs Infants
17.06(5.99–28.30)
Further pooled results
Difference in tTOF90 between children and other age groups (meta-regression)
| Increase in difference (min) (CrI95 CI) | ||
|---|---|---|
| Aminosteroid NMBAsCrI | 21.66 (8.82–34.53) | |
| Sevoflurane/isoflurane maintenanceCrI | 24.73 (7.92–41.43) | |
| −200204060Difference, min (linear scale) |
Original publication
Spontaneous recovery from neuromuscular block after a single dose of a muscle relaxant in pediatric patients: A systematic review using a network meta‐analytic and meta‐regression approach. Paediatr Anaesth. Published 26 April 2024. doi:10.
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