Evaluation of intravenous infusion of labetalol versus magnesium sulfate on cerebral hemodynamics of preeclampsia patients with severe features using transcranial doppler
Authors' conclusion
Both magnesium sulfate and labetalol reduce CPP while maintaining cerebral blood flow (CBF) in preeclampsia patients with severe features.
Study context
- Population
- Singleton pregnant women with late onset preeclampsia with severe features2 equal groups
- Participants
- 60 women
- Comparison
- Labetalol vs MgSO4 infusion
- Primary endpoint
- Cerebral hemodynamics by Transcranial doppler (TCD): Middle cerebral artery (MCA) mean flow velocity, mean end-diastolic velocity, pulsatility index (PI), estimated CPP
- Follow-up
- 1 and 6 hours after administration
Primary result
As reported in the abstract
- Group M: Pulsatility index (PI) 0.77 ± 0.04 at baseline vs 0.66 ± 0.05 at 1 h and 0.66 ± 0.05 at 6 h (p value < 0.001)
- Group M: CPP decreased from 103.3 ± 12.7mmHg to 87.8 ± 10.6mmHg (1 h) and 89.8 ± 10.9mmHg (6 h) (p value < 0.001)
- Group L: PI decreased from 0.77 ± 0.05 at baseline to 0.67 ± 0.05 (1 h) and 0.67 ± 0.06 (6 h) (p value < 0.001)
- Group L: CPP decreased from 103.6 ± 12.6 mmHg to 86.2 ± 13.02mmHg (1 h) and 83.7 ± 14.6mmHg (6 h) (p value < 0.001)
- Within-group changes from baseline
Further findings
Changes in BP and heart rate
- Significantly lower in the labetalol group
Original publication
Evaluation of intravenous infusion of labetalol versus magnesium sulfate on cerebral hemodynamics of preeclampsia patients with severe features using transcranial doppler. J Clin Monit Comput. Published 19 April 2023. doi:10.
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