Prevalence of Point-of-Care Ultrasound Abnormalities and Raised Serum NT-proBNP in Early-Onset Preeclampsia
Authors' conclusion
Lung ultrasound and TTE showed a high prevalence of PIS, systolic dysfunction, and raised LVEDP in women diagnosed with EOPE. PIS was not associated with elevated LVEDP. NT-proBNP level was significantly associated with PIS and elevated LVEDP, however clinical predictive value was limited. Women with EOPE had a higher prevalence of systolic dysfunction than those with LOPE.
Study context
- Population
- Women with early-onset preeclampsia with severe featuresSixty-4 completed
- Exposure
- Pulmonary interstitial syndrome (PIS) vs no PIS for elevated left ventricular end-diastolic pressure (LVEDP); Early onset preeclampsia (EOPE) vs historical late-onset preeclampsia (LOPE) controls
- Outcome
- Association between PIS and elevated LVEDP in EOPE
Methodological detailshistorical controls
- Historical controls
Main finding
As reported in the abstract
- No association between PIS and elevated LVEDP
- P = .53
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| EOPE vs historical controls with LOPEEOPE vs LOPE · significantly higher in EOPE | P < 0.01 |
| EOPE vs historical controls with LOPEEOPE vs LOPE · lower in EOPE | P < 0.01 |
Prevalence of point of care ultrasound (POCUS) abnormalities in EOPE
- PIS
- 23% (95% CI, 14.4-35.4%)
- Diastolic dysfunction
- 52% (95% CI, 39.3-63.8%)
- Systolic dysfunction
- 30% (95% CI, 19.9-42.5%)
- Elevated LVEDP
- 35% (95% CI, 24.2-47.6%)
- Increased optic nerve sheath diameter (ONSD), n (%)
- 2 (3%)
Serum NT-proBNP and its association with PIS and elevated LVEDP
- Association of NT-proBNP with PIS
- P = 0.015
- Association of NT-proBNP with elevated LVEDP
- P = 0.003
- NT-proBNP significantly elevated, median (IQR) 278 [119-678] ng/L
Diagnostic value of NT-proBNP (threshold 125 ng/L)
- Sensitivity for PIS
- 93.3%
- Specificity for PIS
- 34%
- Sensitivity for increased LVEDP
- 90.5%
- Specificity for increased LVEDP
- 40%
- AUC for PIS (limited diagnostic value)
- 0.78
- AUC for elevated LVEDP (limited diagnostic value)
- 0.68
Serum albumin
- No association between serum albumin and PIS, systolic dysfunction, or elevated LVEDP
Original publication
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