ICU sedation, delirium & recovery
Evaluation of nociception in unconscious critically ill patients using a multimodal approach
Authors' conclusion
Detection of nociception varies across different devices in unconscious critically ill patients.
Study context
- Population
- Unconscious (GCS <9, motor response <5) mechanically ventilated adults in the ICU
- Participants
- 80 participants
- Exposure
- Nociception detection after tetanic stimulation by PPI vs Skin Conductance Algesimeter (SCA) vs instantaneous Analgesia Nociception Index (iANI)
- Outcome
- Nociception after tetanic stimulation
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Pupillary response to tetanic stimulation
- Median pupillary dilation [range as printed], %
- 16 [6-25]
- Median PPI
- 5 [2-7]
Physiologic variables after tetanic stimulation
- No significant changes
PPI, iANI and SCA variables by baseline EEG power (low vs normal) (subgroup)
- No differences
Original publication
Evaluation of nociception in unconscious critically ill patients using a multimodal approach. Anaesth Crit Care Pain Med. Published 14 November 2022. doi:10.
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