Evaluation of the need for dosing adaptations in obese patients for surgical antibiotic prophylaxis: a model-based analysis of cefazolin pharmacokinetics
Authors' conclusion
This model-based analysis, using fT>MIC = 100% as a target, showed that cefazolin dosing adaptations are not required for surgical prophylaxis in obese patients.
Study context
- Population
- Obese and nonobese patients receiving 2 g cefazolin i.v. for surgical infection prophylaxisage- and sex-matched
- Participants
- 15 vs 15
- Comparison
- Obese vs Nonobese
- Obesen = 15
- Nonobesen = 15reference
- Outcome
- PTA and CFR in plasma and adipose tissue interstitial space fluid (ISF) for target fT>MIC = 100% (regimen adequate when PTA and CFR ≥90%)
Methodological detailsmodel-based analysis, nonlinear mixed-effects modelling, tissue microdialysis, age- and sex-matched
- Model-based analysis
- Nonlinear mixed-effects modelling
- Tissue microdialysis
- Age- and sex-matched
Main finding
As reported in the abstract
Most suitable cefazolin dosing regimen
| Group | Probability of target attainment (PTA) | Cumulative fraction of response (CFR) |
|---|---|---|
| Obese | >90% | >90% |
| Nonobese | >90% | >90% |
Probability of target attainment (PTA)
Obese>90%
Nonobese>90%
Cumulative fraction of response (CFR)
Obese>90%
Nonobese>90%
Original publication
Evaluation of the need for dosing adaptations in obese patients for surgical antibiotic prophylaxis: a model-based analysis of cefazolin pharmacokinetics. Br J Anaesth. Published 1 February 2025. doi:10.
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