Cardiac arrest & resuscitation
Evaluation of Use of Epinephrine and Time to First Dose and Outcomes in Pediatric Patients With Out-of-Hospital Cardiac Arrest
Main finding · Survival to hospital dischargeResult — go to the resultRR for survival to hospital discharge 2.09 95% CI 1.29–3.40Authors' conclusion
In this study of pediatric patients with OHCA in the US and Canada, epinephrine administration was associated with survival to hospital discharge, while timing of the administration was not associated with survival.
Study context
- Population
- Pediatric patients (<18 years) with out-of-hospital cardiac arrest (OHCA) treated by emergency medical services (EMS), Resuscitation Outcomes Consortium Epidemiologic Registry, 10 sites in the US and Canada, April 2011 to June 2015propensity-matched cohort
- Participants
- 1,432 patients
- Exposure
- Prehospital IV or intraosseous epinephrine vs no epinephrine
- Epinephrinen = 716
- At-riskn = 716reference
- Outcome
- Survival to hospital discharge
Methodological detailstime-dependent propensity-score matched, prospective multicentre registry
- Time-dependent propensity-score matched
- Prospective multicentre registry
Main finding
As reported in the abstract
RR for survival to hospital discharge
2.09
95% CI 1.29–3.40
Events by group
Epinephrine vs At-risk
RR for survival to hospital discharge 2.09 (95% CI 1.29–3.40)
Observational data: associations, not effects.
Further findings
- Time from advanced life support (ALS) arrival to epinephrine
- 9 · median · IQR 6.2–12.1 · minutes
Timing of epinephrine and survival to hospital discharge
- Timing of epinephrine not associated with survival to hospital discharge
- P for interaction = .34
Original publication
Evaluation of Use of Epinephrine and Time to First Dose and Outcomes in Pediatric Patients With Out-of-Hospital Cardiac Arrest. JAMA Netw Open. Published 1 March 2023. doi:10.
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