Evidence-Based Opioid Prescribing Guidelines and New Persistent Opioid Use After Surgery
Main finding · New persistent opioid use (adjusted incidence)Result — go to the resultAdditional percentage point decrease 0.53 percentage point 95% CI 0.36–0.69Authors' conclusion
Evidence-based opioid prescribing guidelines were associated with a significant reduction in the incidence of new persistent opioid use and the quantity of opioids prescribed after surgery.
Study context
- Population
- Opioid-naive Medicare patients undergoing 1 of 6 common surgical procedures
- Participants
- 24,908 vs 118,665
- Comparison
- Michigan vs Outside of Michigan
- Michigann = 24,908
- Outside of Michigann = 118,665reference
- Outcome
- Incidence of new persistent opioid use
Methodological detailsMedicare claims, statewide quality collaborative
- Medicare claims
- Statewide quality collaborative
Main finding
New persistent opioid use (adjusted incidence)
Additional percentage point decrease
0.53 percentage point
95% CI 0.36–0.69
By group
Michigan
2.51%
95% CI 2.35–2.67%
As reported in the abstract
Secondary outcomes
mg oral morphine equivalents (OME)
| Outcome | Michigan | Additional decrease (mg OME) (95% CI) |
|---|---|---|
| Total postoperative opioid prescription quantity (adjusted, OME)Difference-in-differences | 88.6 (95% CI 78.7–98.5) | 55.7 (46.5–65.4) |
| Before guidelines | 199.5 (95% CI 198.3-200.6) |
Original publication
Evidence-Based Opioid Prescribing Guidelines and New Persistent Opioid Use After Surgery. Ann Surg. Published 2 January 2023. doi:10.
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