Surgeon Postoperative Opioid Prescribing Intensity and Risk of Persistent Opioid Use Among Opioid-naive Adult Patients: A Population-based Cohort Study
Main findingResult — go to the resultAdjusted odds ratio 1.18 95% CI 0.83–1.66Authors' conclusion
Surgeons' overall prescribing practices may contribute to persistent opioid use and represent a target for quality improvement. However, the association was highly sensitive to the definition of persistent use used.
Study context
- Population
- Opioid-naive adults undergoing 1 of 4 common surgeries
- Participants
- 112,744 adults
- Exposure
- Surgeon opioid prescribing intensity, highest vs lowest quartile
- Outcome
- Persistent opioid use (≥180 days of opioids supplied within the year after the index date, excluding prescriptions filled within 30 days of the index date)
- Follow-up
- 1 year after surgery
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Adjusted odds ratio
1.18
95% CI 0.83–1.66
By group
Q4 vs Q1
aOR 1.18 (95% CI 0.83–1.66)
Observational data: associations, not effects.
Secondary outcomes
Opioid prescription filled within 7 days after surgery
| Outcome | Q1 | Q4 | aOR (95% CI) | |
|---|---|---|---|---|
| Opioid refill within 30 days | 4.0% | 4.8% | 1.14 (1.04–1.24) | |
| 0.512Adjusted odds ratio (log scale) |
Persistent opioid use, stricter definitions (incl. prescription filled within 7 days of discharge)
- Significant association with surgeon quartile
- up to adjusted odds ratio (AOR) 1.36 1.36 (95% CI 1.25, 1.47)
- Association highly sensitive to the definition of persistent use
Original publication
Surgeon Postoperative Opioid Prescribing Intensity and Risk of Persistent Opioid Use Among Opioid-naive Adult Patients: A Population-based Cohort Study. Ann Surg. Published 6 April 2023. doi:10.
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