ICU sedation, delirium & recovery
Evolution of Clinical Characteristics and Outcomes of Critically Ill Patients 90 Years Old or Older Over a 12-Year Period: A Retrospective Cohort Study
Authors' conclusion
While the patients' clinical characteristics and short-term outcomes have not changed significantly, the long-term mortality of these patients has improved in recent years.
Study context
- Population
- Critically ill patients 90 years old or older admitted to the ICUs of a single academic hospital in Germany, 2008–2019of 92,958 ICU patients
- Participants
- 1,108 patients
- Exposure
- Patients ≥90 years admitted 2013-2019 vs 2008-2013
- First periodn = 391reference
- Second periodn = 717
- Outcome
- Proportion of total ICU admissions aged ≥90 years
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Vasopressor therapy · values in each time period, respectively (first, second)
P = 0.363
ICU mortality · comparable
P = 0.861
Hospital mortality · comparable
P = 0.395
1-year mortality · significantly lower during the second period
P = 0.029
ICU LOS · significantly lower in the first period
P = 0.002
| Outcome | First period | Second period | P value |
|---|---|---|---|
| Charlson Comorbidity IndexMedian | 1 (IQR 1–3) | 1 (IQR 0–2) | P = 0.052 |
| SAPS IIHigher during the first period | 38 (IQR 29–49) | 35 (IQR 27–45) | P = 0.005 |
| Invasive mechanical ventilationValues in each time period, respectively (first, second) | P = 0.250 |
Demographic characteristics
- Similar between the two time periods
Factors associated with 1-year mortality (Cox regression)
- Simplified Acute Physiology Score (SAPS) II, medical cause of admission, mechanical ventilation requirement and vasopressor use associated with 1-year mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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