ICU sedation, delirium & recovery
Association between organ dysfunction during intensive care unit (ICU) stay and post-intensive care syndrome at 1 year after ICU discharge: a prospective cohort study
Main finding · PICS per additional organ dysfunctionResult — go to the resultOdds ratio 2.91 95% CI 1.92–6.00Authors' conclusion
In this exploratory analysis, the breadth of organ system involvement during critical illness, captured by the number of organ dysfunctions, was more strongly associated with PICS at 12 months after ICU discharge and demonstrated greater discriminative ability than any baseline demographics or comorbidities as well as SOFA and APACHE scores.
Study context
- Population
- Adult surgical ICU survivors enrolled September 2023–August 2024
- Participants
- 159 survivors
- Exposure
- Post-Intensive Care Syndrome (PICS) vs No PICS
- PICSn = 49
- Outcome
- PICS (impairment in ≥ 2 of 3 domains) by burden of critical illness (sum of organ dysfunctions during ICU stay)
- Follow-up
- 12 months
Methodological detailssingle-centre, exploratory analysis, ICU exposure data ascertained retrospectively from electronic health records
- Single-centre
- Exploratory analysis
- ICU exposure data ascertained retrospectively from electronic health records
Main finding
PICS per additional organ dysfunction
Odds ratio
2.91
95% CI 1.92–6.00
P < 0.001
Each additional organ dysfunction
OR 2.91 (95% CI 1.92–6.00); P < 0.001
Each additional organ dysfunction, as printed
As reported in the abstract
- PICS prevalence at 12 months
- 49 of 159 (31%)
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Discrimination for PICS (AUC) · 12 monthsOrgan dysfunction count vs Baseline-only model | Organ dysfunction count AUC 0.83 (95% CI 0.75–0.91) · optimism-corrected AUC 0.82 · Baseline-only model AUC 0.60 (95% CI 0.50–0.71) · Admission SOFA AUC 0.63 · APACHE II AUC 0.64 · Three-variable model apparent AUC 0.87 · optimism-corrected AUC 0.83 | DeLong p < 0.001 |
- Discrimination for PICS (AUC): three-variable model exploratory, data-driven, borderline calibration
Baseline demographics and comorbidities
- Did not differ between PICS and no PICS; PICS had longer, more complicated ICU stays and more organ dysfunctions
Original publication
Association between organ dysfunction during ICU stay and post-intensive care syndrome at 1 year after ICU discharge: a prospective cohort study. J Intensive Care. Published 28 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →