ICU sedation, delirium & recovery
Phenotypes of Functional Decline or Recovery in Sepsis ICU Survivors: Insights From a 1-Year Follow-Up Multicenter Cohort Analysis
Authors' conclusion
Four clinical phenotypes of ICU sepsis survivors might contribute to a deeper understanding of post-sepsis trajectories and an individualized treatment approach.
Study context
- Population
- Consecutive adults diagnosed with sepsis at ICU admission who survived to discharge, 21 mixed ICUs, November 2020–April 2022
- Participants
- 220 adults · 21 ICUs
- Exposure
- Four phenotypes of sepsis-associated post-intensive care syndrome (PICS) at hospital discharge
- Group 1n = 62
- Group 2n = 55
- Group 3n = 53
- Group 4n = 50
- Outcome
- Phenotypes of sepsis-associated PICS by physical, cognitive and psychiatric function and QoL
- Follow-up
- Hospital discharge
Methodological detailsmulticentre, 1-year follow-up, phenotyping (cluster analysis)
- Multicentre
- 1-year follow-up
- Phenotyping (cluster analysis)
Main finding
As reported in the abstract
PICS phenotypes
- Four phenotypes identified: no, mild, moderate and severe PICS
- 4
Observational data: associations, not effects.
Further findings
Functional trajectories over 1 year · 12 months
- Functional decline and recovery significantly varied among phenotypes
- Physical and cognitive PICS in group 2 improved by 3 months; disabilities in groups 3 and 4 remained over the year
- Psychiatric PICS in groups 3 and 4 ameliorated; depression symptoms in group 4 still evident at 12 months
Quality of life (QoL) and employment
- All groups: persistent moderate to severe reduced QoL and low employment
- 0-50%
Survival
- Survival in group 4 continuously decreased
Original publication
Phenotypes of Functional Decline or Recovery in Sepsis ICU Survivors: Insights From a 1-Year Follow-Up Multicenter Cohort Analysis. Crit Care Med. Published 24 February 2025. doi:10.
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