ICU sedation, delirium & recovery
Long-Lasting Mental Disorders in Caregivers of ICU Sepsis Survivors and Their Association With Patients’ Post-Intensive Care Syndrome: A Prospective Multicenter Cohort Study
Authors' conclusion
The prevalence of mental PICS-F in caregivers of ICU sepsis survivors was frequent and long-lasting over the first year after hospital discharge. Since it was most strongly associated with patients' mental disorders rather than physical or cognitive impairments, the mental PICS domain in patients may be an important indicator of PICS-F and should be considered in future studies.
Study context
- Population
- Caregivers (the next of kin) of ICU patients diagnosed with sepsis between November 2020 and April 2022, assessed with the patients at 3, 6, and 12 months after hospital discharge by telephone and mailcaregiver-patient dyads analyzed
- Participants
- Ninety-four participants
- Exposure
- Association between patient post-intensive care syndrome (PICS) and caregiver mental post-intensive care syndrome-family (PICS-F), by mixed-effects logistic regression
- Outcome
- Caregiver mental disorders (mental post-intensive care syndrome-family [PICS-F]), prevalence
- Follow-up
- 3 and 12 months after hospital discharge
Methodological detailsmulticenter (twenty-one mixed ICUs)
- Multicenter (twenty-one mixed ICUs)
Main finding
As reported in the abstract
Prevalence of mental PICS-F at 3 months
43%
Prevalence of mental PICS-F at 12 months
42%
Observational data: associations, not effects.
Further findings
Caregiver PICS-F associated with presence of PICS symptoms in patients
| Adjusted odds ratio for PICS-F (95% CI) | P value | ||
|---|---|---|---|
| Presence of PICS symptoms in patientsMixed-effects logistic regression | 3.00 (1.54–5.88) | P < 0.01 | |
| 0.20.5125Adjusted odds ratio for PICS-F (log scale) |
Caregiver PICS-F associated with individual patient PICS domains
| Adjusted odds ratio for PICS-F (CI) | P value | ||
|---|---|---|---|
| Mental PICS in patients | 3.71 (2.03–6.77) | P < 0.01 | |
| 0.10.31310Adjusted odds ratio for PICS-F (log scale) |
Presence of PICS symptoms in patients · 3 to 12 months after hospital discharge
- Patients with PICS symptoms at 3 months
- 82%
- Patients with PICS symptoms at 12 months
- 62%
Caregiver PICS-F associated with individual patient PICS domains
- Physical and cognitive impairments in patients were not significantly associated with PICS-F
Characteristics of caregivers and patients (descriptive)
- Caregiver age, median (yr)
- 67 years old (55-79 yr old)
- Caregivers male
- 31 (33.0%)
- Caregivers who were spouses
- 41 (43.6%)
- Patient age, median (yr)
- 74 years old (69-82 yr old)
- Patients male
- 54 (57.4%)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →