Exploring biomarkers for diagnosing and predicting organ dysfunction in patients with perioperative sepsis: a preliminary investigation
Authors' conclusion
Serum CatB, S100-A9, VCAM-1, prosaposin, and NGAL may be novel markers for preoperative diagnosis and postoperative prediction of organ dysfunction.
Study context
- Population
- Emergency surgery patients with perioperative sepsis
- Exposure
- Septic vs control emergency surgery patients
- Outcome
- Serum protein levels (enzyme-linked immunosorbent assay (ELISA))
Methodological detailspreliminary, single-centre
- Preliminary
- Single-centre
Main finding
As reported in the abstract
- Cathepsin B (CatB), VCAM-1, neutrophil gelatinase-associated lipocalin (NGAL), S100-A9, prosaposin and thrombospondin-1 significantly increased in sepsis vs controls
- p < 0.001
Observational data: associations, not effects.
Further findings
Preoperative renal failure diagnosis model (bootstrap internal validation)
- C-index (95% CI 0.843-0.954); good discrimination and calibration
- 0.898
Original publication
Exploring biomarkers for diagnosing and predicting organ dysfunction in patients with perioperative sepsis: a preliminary investigation. Perioper Med (Lond). Published 24 July 2024. doi:10.
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