Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries
Errata to this article were published (BJA Open, 28 Feb 2024 ↗ · 6 Mar 2024 ↗)
Authors' conclusion
High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this.
Study context
- Population
- Abdominal surgery patients in Nigeria, India and South Africa
- Comparison
- High vs low fraction of inspired oxygen (FiO2)
- Outcome
- Cost-effectiveness at preventing surgical site infections (SSIs) (effectiveness: percentage of SSIs; costs in US dollars)
- Follow-up
- 30 days after surgery
Methodological detailsdecision-analytic model, healthcare perspective, costs in US dollars, Model inputs: unbundled data of an ongoing pilot trial, published literature, and a cost survey in Nigeria, India and South Africa
- Decision-analytic model
- Healthcare perspective
- Costs in US dollars
- Model inputs: unbundled data of an ongoing pilot trial, published literature, and a cost survey in Nigeria, India and South Africa
Main finding
As reported in the abstract
Average cost and SSIs
Each group vs low FiO2Percentage point reduction in SSIs (7.33% vs 8.38%), percentage point (95% CI)
High FiO2
−1.05(−1.14 to −0.90)
- High FiO2
- difference in costs (Nigeria; $216 vs $222) −6 $ (95% CI -$13 to -$1)
- High FiO2
- difference in costs (India; $184 vs $195) −11 $ (95% CI -$15 to -$6)
- High FiO2
- difference in costs (South Africa; $1164 vs $1257) −93 $ (95% CI -$132 to -$65)
Original publication
Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries. BJA Open. Published 15 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →