Respiratory failure & ventilation
Effect of intraoperative high positive end-expiratory pressure with recruitment manoeuvres versus low positive end-expiratory pressure on postoperative lung function in obese adults: a substudy of the protective ventilation in obese patients randomised controlled trial
Primary result · Change in FEV1 from baseline to POD 1Result — go to the resultBetween-group effect 0.0 L 95% CI −0.4 to 0.4Authors' conclusion
In obese patients undergoing abdominal surgery with low tidal volume ventilation, high PEEP with recruitment manoeuvers did not improve postoperative spirometric outcomes or oxygen saturation compared with low PEEP without routine recruitment manoeuvres.
Study context
- Population
- Adults with BMI ≥35 kg·m-2 undergoing abdominal surgery, Ghent University Hospital, Belgiumpostoperative spirometry available
- Participants
- 44 adults
- Comparison
- High PEEP vs Low PEEP
- High PEEPn = 21
- Low PEEPn = 23reference
- Primary endpoint
- Change in FEV1 from baseline to POD 1
- Follow-up
- Postoperative day 1
Methodological detailssingle-centre, substudy
- Single-centre
- Substudy
Primary result
As reported in the abstract
Between-group effect
0.0 L
95% CI −0.4 to 0.4
P = 0.89
Change by group
Low PEEP
−0.90
SD 0.68 · L
High PEEP
−0.93
SD 0.66 · L
Secondary outcomes
Spirometry variables and oxygen saturation
- No differences observed in secondary outcomes
Postoperative lung function
- Declined in all patients
Original publication
Effect of intraoperative high positive end-expiratory pressure with recruitment manoeuvres versus low positive end-expiratory pressure on postoperative lung function in obese adults: a substudy of the protective ventilation in obese patients randomised controlled trial. BJA Open. Published 30 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →