Perioperative medicine & outcomes
Association of plasma biomarkers of lung injury with positive end expiratory pressure and postoperative pulmonary complications in obese surgical patients: A substudy of the PROBESE randomised controlled trial
Authors' conclusion
In this subgroup, choice of PEEP did not affect postoperative biomarkers of lung injury. Irrespective of PEEP, PPCs were associated with an increase in plasma levels of these biomarkers, but their predictive capability was poor.
Study context
- Population
- Obese patients at risk for postoperative pulmonary complications (PPCs) undergoing abdominal surgery, six tertiary care centres in the US and Europe
- Participants
- 95 vs 96
- Comparison
- Intra-operative high positive end expiratory pressure (PEEP) with recruitment manoeuvres vs low PEEP
- High PEEPn = 95
- Low PEEPn = 96reference
- Primary endpoint
- Association between absolute postoperative plasma levels of receptor for advanced glycation end-products (RAGE) and intra-operative PEEP
Methodological detailsprospective substudy, multicentre
- Prospective substudy
- Multicentre
Primary result
As reported in the abstract
Postoperative plasma RAGE
- Postoperative plasma concentrations of RAGE and other biomarkers did not differ between groups
Secondary outcomes
Median
| Outcome | Low PEEP | High PEEP | P value |
|---|---|---|---|
| Relative increase of RAGE during surgery | 1.2 (IQR 1.0–1.6) | 1.1 (IQR 0.9–1.3) | P = 0.012 |
Relative increase of IL-6, patients with vs without PPCs
- PPCs: higher postoperative plasma levels and relative increase of IL-6 (fold change)
- 26.3 [12.6 to 139.5] vs. 15.1 [3.7 to 38.7]
Predictive ability of biomarkers for PPCs (receiver operating curve-area under the curve (ROC-AUC))
- ROC-AUC less than 0.7 for all biomarkers
Original publication
Association of plasma biomarkers of lung injury with positive end expiratory pressure and postoperative pulmonary complications in obese surgical patients: A substudy of the PROBESE randomised controlled trial. Eur J Anaesthesiol. Published 20 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →