Perioperative medicine & outcomes
Win Ratio approach for the composite outcome of postoperative pulmonary complications: Secondary analysis of a harmonised and pooled database of three randomised clinical trials
Pooled result · Win ratio, hierarchical compositeResult — go to the resultWin ratio 1.00 95% CI 0.92–1.09Authors' conclusion
No beneficial effects of high PEEP compared with low PEEP were found in this win ratio analysis.
Study context
- Population
- Patients undergoing GA for surgery
- Participants
- 3,774 patients · 3 multicentre RCTs
- Comparison
- High vs low positive end-expiratory pressure (PEEP)
- Outcome
- Hierarchical composite:
- All-cause hospital mortality
- Hospital LOS
- Need for postoperative mechanical ventilation
- Severe pulmonary complications
- Mild pulmonary complications
Methodological detailswin ratio analysis, re-analysis of REPEAT study
- Win ratio analysis
- Re-analysis of REPEAT study
Pooled result
Win ratio, hierarchical composite
Win ratio
1.00
95% CI 0.92–1.09
High PEEP vs Low PEEP
win ratio 1.00 (95% CI 0.92–1.09)
As reported in the abstract
Further pooled results
Components of the composite, high PEEP losses vs wins
- Hospital mortality: higher % losses than wins (losses vs wins)
- 1.1 vs. 0.9%
- Hospital LOS: higher % losses than wins (losses vs wins)
- 33.8 vs. 33.2%
- Postoperative invasive mechanical ventilation: comparable % losses and wins
- 0.2 vs. 0.2%
- Severe complications: higher % wins (wins vs losses)
- 2.5 vs. 2.1%
- Mild complications: higher % ties (ties vs wins vs losses)
- 18.7 vs. 3.9% wins vs. 3.3% losses
Original publication
Win Ratio approach for the composite outcome of postoperative pulmonary complications: Secondary analysis of a harmonised and pooled database of three randomised clinical trials. Eur J Anaesthesiol. Published 18 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →