Exploring the relationship between capillary refill time, skin blood flow and microcirculatory reactivity during early resuscitation of patients with septic shock: a pilot study
Authors' conclusion
Abnormal CRT values observed during early septic shock resuscitation are associated with impaired skin blood flow, and abnormal skin microvascular reactivity.
Study context
- Population
- Patients with early septic shock (multimodal perfusion and hemodynamic monitoring for 24 h; time-points 0, 1 and 24 h)plus 10 healthy volunteers
- Participants
- 12 patients
- Exposure
- Abnormal vs normal capillary refill time (CRT)
- Outcome
- Association of abnormal CRT with impaired skin blood flow (laser doppler) and microvascular reactivity
Methodological detailshealthy volunteer reference values
- Healthy volunteer reference values
Main finding
As reported in the abstract
Skin blood flow (pooled data)
P = 0.0001
- CRT strongly associated with skin blood flow (SBF) (R2)
- 0.76
Observational data: associations, not effects.
Further findings
Baseline characteristics
- Median age, years
- 70
- 28-day mortality
- 50%
- Baseline CRT, seconds
- 3.3 [2.7-7.3]
Original publication
Exploring the relationship between capillary refill time, skin blood flow and microcirculatory reactivity during early resuscitation of patients with septic shock: a pilot study. J Clin Monit Comput. Published 10 December 2022. doi:10.
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