Extremely early initiation of vasopressors might not decrease short-term mortality for adults with septic shock: a systematic review and meta-analysis
Pooled result · Short-term mortality (2 RCTs and 3 quasi-experimental studies, n = 3,757)Result — go to the resultOdds ratio 0.66 95% CI [0.36, 1.19]Authors' conclusion
Our findings found that earlier initiation of vasopressor therapy, particularly within one to three hours after the diagnosis of septic shock, may be associated with reduced short-term mortality in certain subgroups.
Study context
- Population
- Patients with septic shock
- Participants
- 6,661 patients · 11 studies
- Comparison
- Early vs late vasopressor initiation
- Outcome
- Short-term mortality
Methodological detailssubgroup analyses by initiation timing
- Subgroup analyses by initiation timing
Pooled result
As reported in the abstract
Short-term mortality (2 RCTs and 3 quasi-experimental studies, n = 3,757)
Odds ratio
0.66
95% CI [0.36, 1.19]
Early vs Late
OR 0.66 (95% CI [0.36, 1.19])
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Short-term mortality, subgroup with early but not extremely early initiation (one to three hours) (subgroup)I²: 0% | 0.70 ([0.60, 0.82]) | |
| Short-term mortality, subgroup using septic shock diagnosis as time zero (subgroup)I²: 39% | 0.64 ([0.48, 0.85]) | |
| 0.512Odds ratio (log scale) |
Original publication
Extremely early initiation of vasopressors might not decrease short-term mortality for adults with septic shock: a systematic review and meta-analysis. Ann Intensive Care. Published 27 January 2025. doi:10.
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