Paediatric anaesthesia & critical care
Factors associated with persistent postoperative hyperthermia in pediatric craniocerebral injury: a retrospective cohort study and preliminary risk score
Authors' conclusion
Persistent postoperative hyperthermia is a prevalent complication in children following craniocerebral injury surgery, which is influenced by multiple factors. The identified factors are independently associated with this outcome, although causality cannot be inferred.
Study context
- Population
- Children who underwent craniocerebral injury surgery
- Participants
- 238 children
- Exposure
- Persistent vs non-persistent postoperative hyperthermia
- Outcome
- Prevalence of and factors independently associated with persistent postoperative hyperthermia
- Follow-up
- First 72 h postoperatively
Methodological detailspreliminary risk score
- Preliminary risk score
Main finding
As reported in the abstract
Persistent postoperative hyperthermia: incidence and independent factors (multivariate logistic regression)
Odds ratio (95% CI)
Age ≤ 5 years
3.516(2.108–5.854)
Severe craniocerebral injury
6.442(3.285–12.638)
Elevated postoperative ICP (≥ 20 mmHg)
4.598(2.683–7.895)
Postoperative drainage tube indwelling time ≥ 72 h
4.002(2.356–6.817)
Pulmonary infection
5.438(3.126–9.457)
MRSA infection
3.078(1.756–5.392)
- Incidence of persistent postoperative hyperthermia
- 28.99%
Observational data: associations, not effects.
Further findings
Preliminary predictive model performance (in the cohort)
- Sensitivity
- 0.754
- Specificity
- 0.879
- Youden index
- 0.633
- Estimates likely optimistic; require external validation
Original publication
Factors associated with persistent postoperative hyperthermia in pediatric craniocerebral injury: a retrospective cohort study and preliminary risk score. Perioper Med (Lond). Published 9 June 2026. doi:10.
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