ICU sedation, delirium & recovery
Factors associated with cancer treatment resumption after ICU stay in patients with solid tumors
Main finding · Inability to receive cancer treatment after ICU stay, by delta PS (difference between PS after and before ICU stay)Result — go to the resultOdds ratio 0.34 95% CI 0.18–0.56Authors' conclusion
Delta PS, before and after ICU stay, stands out as a critical determinant of cancer treatment resumption and survival after ICU stay.
Study context
- Population
- Patients with solid tumors admitted to the ICU, French University-affiliated Hospital, 2014–2019136 ICU survivors
- Participants
- 219 patients
- Outcome
- Factors associated with cancer treatment resumption after ICU stay
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Inability to receive cancer treatment after ICU stay, by delta PS (difference between PS after and before ICU stay)
Odds ratio
0.34
95% CI 0.18–0.56
P < 0.001
Delta PS
OR 0.34 (95% CI 0.18–0.56); P < 0.001
Observational data: associations, not effects.
Further findings
1-year mortality in ICU survivors, by delta performance status (PS)
| HR for death (95% CI) | P value | ||
|---|---|---|---|
| Delta PSIndependently associated | 1.76 (1.34–2.31) | P < 0.001 | |
| 0.512HR for death (log scale) |
| Outcome | Median difference (95% CI) | P value | |
|---|---|---|---|
| PS decline following ICU stayAfter ICU stay vs Before ICU stay | - 1.5 (−1.5-1.0) | P < 0.001 | |
| −2−1012Difference (linear scale) |
Factors associated with poor PS after ICU stay
| OR (95% CI) | P value | ||
|---|---|---|---|
| PS before ICU stayIndependently associated | 3.73 (2.01–7.82) | P < 0.001 | |
| LOSIndependently associated | 1.23 (1.06–1.49) | p value 0.018 | |
| 0.10.31310Odds ratio (log scale) |
Median survival by cancer treatment resumption
P < 0.001
Cancer treatment after ICU discharge (ICU survivors)
- Received cancer treatment after ICU discharge
- 81 (59.6%)
- 136 ICU survivors
Poor PS (3 or 4)
- At ICU admission
- 16.2%
- After ICU stay (survivors)
- 44.5%
Survival
- At ICU discharge
- 62.3% (n = 136)
- At 1 year
- 27.3% (n = 59)
- At 3 years
- 17.1% (n = 37)
Original publication
Factors associated with cancer treatment resumption after ICU stay in patients with solid tumors. Ann Intensive Care. Published 31 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →