Factors related to mortality in critically ill histoplasmosis: a multicenter retrospective study in Guadeloupe and French Guyana
Authors' conclusion
Histoplasmosis requiring ICU admission is a protean disease with multiple and severe organ involvement. Immunodeficiency is found in most patients. The prognosis remains severe despite appropriate treatment and is worsened by late treatment initiation.
Study context
- Population
- Patients admitted to 2 intensive care units (ICUs) (French Guyana, Guadeloupe) for culture-proven histoplasmosis, January 2014 to August 202265% men
- Participants
- 40 patients
- Outcome
- Risk factors at ICU admission associated with death
- Follow-up
- 30 days
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Factors independently associated with 30-day mortality (multivariate analysis)
Odds ratio (95% CI)
SOFA score
1.5(1.1–2.1)
Time between symptom onset and treatment, per day
1.1(1.0–1.1)
Hemophagocytic lymphohistiocytosis
6.4(1.1–47.5)
Per day, as printed
Observational data: associations, not effects.
Further findings
30-day mortality
- 30-day mortality
- 53%
Baseline features
- Median age (years)
- 56
- Simplified acute physiologic score (SAPS) II
- 65
- HIV
- 58%
- Other immunodeficiency
- 28%
- No identified immunodeficiency
- 14%
Organ failure within first 24 h of ICU admission
- Acute respiratory failure
- 85%
- Shock
- 78%
- Coma
- 30%
- Hemophagocytic lymphohistiocytosis
- 48%
Organ support
- Mechanical ventilation
- 78%
- RRT
- 55%
Original publication
Factors related to mortality in critically ill histoplasmosis: a multicenter retrospective study in Guadeloupe and French Guyana. Ann Intensive Care. Published 21 April 2023. doi:10.
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