Feeding-associated hypophosphatemia in critically ill patients. A multicentre, observational study
Authors' conclusion
In a large group of critically ill patients, almost one in seven patients experienced moderate to severe hypophosphatemia after starting to consume calories. The dose of caloric intake and early nutrition initiation were linked to its development. Additionally, moderate to severe hypophosphatemia was independently associated with a higher risk of 30-day hospital mortality.
Study context
- Population
- Critically ill patients from six ICUs in Queensland, Australia, receiving nutrition
- Participants
- 10,672 patients · 6 ICUs
- Exposure
- Moderate/severe feeding-associated hypophosphataemia vs control
- Moderate/severe feeding-associated hypophosphatemian = 1,298
- Outcome
- Incidence of moderate to severe feeding-associated hypophosphataemia
- Follow-up
- Within 24 h of nutrition
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Moderate to severe feeding-associated hypophosphataemia
13 %
1298 events
Observational data: associations, not effects.
Further findings
Crude hospital mortality
P < 0.001
30-day hospital mortality (adjusted for confounders)
| HR (95 % CI) | ||
|---|---|---|
| Moderate-severe feeding-associated hypophosphataemiaAfter adjustment for confounders | 1.30 (1.08–1.56) | |
| 0.512Hazard ratio (log scale) |
Factors independently associated with developing feeding-associated hypophosphataemia
| aOR (95 % CI) | ||
|---|---|---|
| Caloric quantity | 1.06 (1.02–1.10) | |
| Feeding commenced within 48 h of admission | 1.56 (1.28–1.91) | |
| Insulin on day of feeding start | 1.22 (1.07–1.40) | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
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