Fetal growth restriction, placental ischemic lesions and near-infrared spectroscopy evaluation of maternal tissue oxygenation in preeclampsia (the FINE study): a prospective observational study
Authors' conclusion
Baseline thenar tissue oxygen saturation showed associations with fetal growth restriction and placental ischemic lesions, whereas selected vascular occlusion test responses did not differ between groups.
Study context
- Population
- Women with preeclampsia
- Participants
- 33 vs 39
- Exposure
- Thenar NIRS parameters by fetal growth restriction and placental ischemic lesions
- Fetal growth restrictionn = 33
- Placental ischemic lesionsn = 39
- Outcome
- Baseline tissue oxygen saturation
Methodological detailssingle-centre, post hoc sensitivity analyses
- Single-centre
- Post hoc sensitivity analyses
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)P value
Fetal growth restriction
1.16(1.03–1.32)
P = 0.02Placental ischemic lesions
1.17(1.03–1.34)
P = 0.02Observational data: associations, not effects.
Further findings
Baseline tissue oxygen saturation, additionally adjusted for gestational age (post hoc sensitivity analysis)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Fetal growth restrictionNeither association remained statistically significant | 1.07 (0.93–1.22) | P = 0.37 | |
| Placental ischemic lesionsNeither association remained statistically significant | 1.10 (0.94–1.29) | P = 0.23 | |
| 0.512Adjusted odds ratio (log scale) |
Vascular occlusion test-derived parameters (desaturation slope, resaturation slope, hyperemic AUC)
- No statistically significant between-group differences
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Fetal growth restriction, placental ischemic lesions and near-infrared spectroscopy evaluation of maternal tissue oxygenation in preeclampsia (the FINE study): a prospective observational study. Int J Obstet Anesth. Published 18 September 2026. doi:10.
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