Cardiac arrest & resuscitation
Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (TEMP‐CARE): A study protocol for a randomized clinical trial
Study context
- Population
- Nontraumatic/nonhemorrhagic OHCA patients following hospital admissionplanned enrolment
- Participants
- 3,500 patients
- Planned comparison
- Device vs No device
- Primary endpoint
- All-cause mortality
- Follow-up
- 6 months post-randomization
Methodological details2 × 2 × 2 factorial (STEPCARE), international, multicentre, parallel-group, investigator-initiated, superiority, blinded neurological prognostication, Sample size to detect a 5.6% absolute risk reduction (90% power, alpha .05), Secondary outcomes: poor functional outcome at 6 months, ICU-related serious adverse events, overall health status at 6 months
- 2 × 2 × 2 factorial (STEPCARE)
- International
- Multicentre
- Parallel-group
- Investigator-initiated
- Superiority
- Blinded neurological prognostication
- Sample size to detect a 5.6% absolute risk reduction (90% power, alpha .05)
- Secondary outcomes: poor functional outcome at 6 months, ICU-related serious adverse events, overall health status at 6 months
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (TEMP‐CARE): A study protocol for a randomized clinical trial. Acta Anaesthesiol Scand. Published 13 April 2025. doi:10.
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