Cardiac arrest & resuscitation
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events ( STEPCARE ‐ Major Adverse Kidney Events (MAKE) ): A Protocol for a Pre‐Planned Sub‐Study of a Randomized Clinical Trial
Study context
- Population
- Post-cardiac arrest patientsplanned, main trial
- Participants
- 3,500 patients
- Planned comparison
- Deep sedation for 36 h vs minimal sedation; fever management with vs without feedback-controlled device; Mean arterial pressure (MAP) target ≥ 65 mmHg vs ≥ 85 mmHg
- Primary endpoint
- MAKE: composite of death from any cause by day 30, initiation of Kidney Replacement Therapy (KRT), or persistent renal dysfunction (final creatinine ≥ 200% of baseline at discharge from primary hospital or at day 30, whichever first)
- Follow-up
- Day 30
Methodological detailspredefined prospective sub-study, international, 2 × 2 × 2 factorial
- Predefined prospective sub-study
- International
- 2 × 2 × 2 factorial
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events ( STEPCARE ‐ MAKE ): A Protocol for a Pre‐Planned Sub‐Study of a Randomized Clinical Trial. Acta Anaesthesiol Scand. Published 15 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →