Cardiac arrest & resuscitation
Impact of Higher Versus Lower Blood Pressure Targets on Pulmonary Vascular Hemodynamics During Intensive Care After Out‐of‐Hospital Cardiac Arrest
Primary result · Calculated PVRResult — go to the resultMean difference −0.16 to −0.30 95% CI −0.31 to 0.11Authors' conclusion
In comatose OHCA survivors, targeting a higher MAP increased pulmonary artery pressures, PCWP, RV-CPO, heart rate, and cardiac output. The proportionally greater increase in cardiac output over pulmonary artery pressures resulted in a decreased calculated PVR.
Study context
- Population
- Comatose out-of-hospital cardiac arrest (OHCA) survivors with pulmonary artery catheter hemodynamic assessment for 48 h after ICU admission
- Participants
- 730 survivors
- Comparison
- High vs low mean arterial pressure (MAP) target
- Primary endpoint
- Calculated pulmonary vascular resistance (PVR)
Methodological detailsdouble-blinded, substudy, Median time randomisation to pulmonary artery catheters (PAC) insertion 1.3 h
- Double-blinded
- Substudy
- Median time randomisation to PAC insertion 1.3 h
Primary result
Calculated PVR · first 24 h
Mean difference
−0.16 to −0.30
95% CI −0.31 to 0.11
As reported in the abstract
Secondary outcomes
| Outcome | Estimate |
|---|---|
| Mean pulmonary artery pressure (mPAP)Consistently higher in high-MAP; range over time points | mean difference 1.11-1.71 mmHg (95% CI 0.12–2.59) |
| RV cardiac power output (RV-CPO)Lower in low-MAP throughout; largest difference at 48 h | mean difference 0.01-0.04 W (95% CI 0.00–0.07) |
| Pulmonary capillary wedge pressure (PCWP) · first 12 hSignificantly lower in low-MAP; decreased in both groups | mean difference 1.06-1.40 mmHg (95% CI 0.25–2.38) |
Original publication
Impact of Higher Versus Lower Blood Pressure Targets on Pulmonary Vascular Hemodynamics During Intensive Care After Out‐of‐Hospital Cardiac Arrest. Acta Anaesthesiol Scand. Published 3 July 2026. doi:10.
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