Cardiac arrest & resuscitation
Acute kidney injury after out-of-hospital cardiac arrest
Authors' conclusion
In comatose patients who had been resuscitated after OHCA, patients developing AKI, with or without initiation of CKRT, had a worse 1-year overall survival compared to non-AKI patients.
Study context
- Population
- Comatose adult out-of-hospital cardiac arrest (OHCA) patients with presumed cardiac cause and sustained return of spontaneous circulation (ROSC), without prior dialysis-dependent kidney disease, surviving ≥48 h789 enrolled in trial
- Participants
- 759 patients
- Comparison
- Acute kidney injury (AKI) with continuous kidney replacement therapy (CKRT) and AKI without CKRT vs no AKI
- AKI no CKRTn = 177
- AKI CKRTn = 77
- Primary endpoint
- Overall survival according to AKI group
- Follow-up
- 365 days
Methodological detailssub-study, adjusted Cox proportional hazard models
- Sub-study
- Adjusted Cox proportional hazard models
Primary result
As reported in the abstract
Overall survival within 365 days by AKI group
Each group vs no AKIAdjusted HR for death (reduced overall survival) (95% CI)
AKI CKRT
1.75(1.13–2.70)
AKI no CKRT
1.76(1.30–2.39)
Further findings
Incidence of AKI (KDIGO)
- Developed AKI
- 254 (33.5%)
Peri-arrest characteristics
- AKI CKRT patients had longer time-to-ROSC and worse metabolic derangement at admission
Original publication
Acute kidney injury after out-of-hospital cardiac arrest. Crit Care. Published 18 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →