Cardiac arrest & resuscitation
Neurofilament light chain for prognostication after cardiac arrest-first steps towards validation
Authors' conclusion
The results of this investigation confirm the prognostic value of NfL for identification of risk of poor neurologic outcome after cardiac arrest.
Study context
- Population
- Comatose OHCA patients in the BOX trial with ≥1 plasma biobank sample at 24–48 hNfL at 24 or 48 h
- Participants
- 638 patients
- Comparison
- NfL 24 h vs NfL 48 h
- Outcome
- Prediction of poor neurologic outcome (CPC > 2) by AUROC; performance of previously identified cut-offs for 100% specificity
- Follow-up
- 1 year
Methodological detailsvalidation of previously identified cut-offs, biobank substudy of the BOX trial
- Validation of previously identified cut-offs
- Biobank substudy of the BOX trial
Performance
As reported in the abstract
Poor neurologic outcome (CPC > 2)
| Test or model | Area under the receiver operator curve (AUROC) | Specificity (cut-off 1232 pg/mL) | False-positive | Specificity (cut-off 1539 pg/ml) |
|---|---|---|---|---|
| NfL 24 h | 0.95 | 98% | 7 (1.4%) | |
| NfL 48 h | 0.95 | 7 (1.3%) | 98% |
Area under the receiver operator curve (AUROC)
NfL 24 h0.95
NfL 48 h0.95
Specificity (cut-off 1232 pg/mL)
NfL 24 h98%
NfL 48 h— not stated in the abstract
False-positive
NfL 24 h7 (1.4%)
NfL 48 h7 (1.3%)
Specificity (cut-off 1539 pg/ml)
NfL 24 h— not stated in the abstract
NfL 48 h98%
Original publication
Neurofilament light chain for prognostication after cardiac arrest-first steps towards validation. Crit Care. Published 6 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →