Cardiac arrest & resuscitation
Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest
Authors' conclusion
First measured SvO2 after resuscitation from OHCA was inversely associated with mortality and renal failure. If SvO2 and CI were below median, the risk of poor outcomes increased significantly.
Study context
- Population
- Comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA) with pulmonary artery catheters after ICU admissionof 789 in BOX-trial
- Participants
- 565 patients
- Primary endpoint
- All-cause mortality and renal failure (need for RRT)
- Follow-up
- 1 year
Methodological detailshemodynamic substudy, cohort
- Hemodynamic substudy
- Cohort
Primary result
As reported in the abstract
All-cause mortality and renal failure by first measured CI and SvO2
- Low CI at admission not significantly associated with mortality (multivariable)
- p = 0.14
- SvO2 and mortality, aHR per 5% increase in SvO2
- 0.91 (0.84-0.98), p = 0.01
- SvO2 and renal failure, aOR per 5% increase in SvO2
- 0.73 [0.62-0.86], p = 0.001
- Lower CI and lower SvO2 combined, mortality aHR
- 1.54 (1.06-2.23)
- Lower CI and lower SvO2 combined, renal failure aOR
- 5.87 [2.34-14.73]
Further findings
First measured haemodynamic values
- First CI, median (l/min/m²)
- 1.7 (1.4-2.1)
- First SvO2, median (%)
- 67 (61-73)
- CI < median with SvO2 > median
- 222 (39%)
- Low SvO2 with CI < median
- 59 (11%)
Original publication
Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest. Crit Care. Published 27 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →