Combined effects of targeted blood pressure, oxygenation, and duration of device-based fever prevention after out-of-hospital cardiac arrest on 1-year survival: post hoc analysis of a randomized controlled trial
Authors' conclusion
There was no difference in 1-year mortality rates for a low compared to high blood pressure target, a liberal compared to restrictive oxygenation target, or a longer compared to shorter duration of device-based fever prevention after cardiac arrest. No combination of the interventions affected these findings.
Study context
- Population
- Comatose resuscitated OHCA patients
- Participants
- 789 participants
- Comparison
- Low vs high BP target, restrictive vs liberal oxygenation target, 36 vs 72 h device-based fever prevention
- Low BP targetn = 396
- High BP targetn = 393reference
- Restrictive oxygenationn = 394
- Liberal oxygenationn = 395reference
- 36 hn = 393
- 72 hn = 396reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 1 year
Methodological detailstwo-centre, factorial
- Two-centre
- Factorial
Primary result
As reported in the abstract
1-year mortality
Hazard ratio (CI)P value
Low BP target vs High BP target
0.92(0.73–1.16)
P = 0.47Restrictive oxygenation vs Liberal oxygenation
0.92(0.73–1.16)
P = 0.4636 h vs 72 h
0.98(0.78–1.24)
P = 0.89Original publication
Combined effects of targeted blood pressure, oxygenation, and duration of device-based fever prevention after out-of-hospital cardiac arrest on 1-year survival: post hoc analysis of a randomized controlled trial. Crit Care. Published 12 January 2024. doi:10.
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