Cardiac arrest & resuscitation
Higher versus lower blood pressure targets after cardiac arrest: Systematic review with individual patient data meta-analysis
Authors' conclusion
Targeting a higher MAP compared to a lower MAP is unlikely to reduce mortality or improve neurologic recovery after CA.
Study context
- Population
- Patients after cardiac arrest and resuscitation
- Participants
- 1,087 patients · 4 trials
- Comparison
- Higher vs lower mean arterial pressure (MAP) target after cardiac arrest
- Outcome
- All-cause mortality and poor neurologic recovery (mRS 4-6 or CPC 3-5)
- Follow-up
- 180 days
Methodological detailstrial sequential analysis, All included trials at low risk of bias (RoB 2)
- Trial sequential analysis
- All included trials at low risk of bias (RoB 2)
Pooled result
As reported in the abstract
Higher MAP vs Lower MAPRelative risk (95% CI)
180-day all-cause mortality
1.08(0.92–1.26)
Poor neurologic recovery
1.01(0.86–1.19)
Safety
Serious adverse events
- No difference between higher and lower MAP
Original publication
Higher versus lower blood pressure targets after cardiac arrest: Systematic review with individual patient data meta-analysis. Resuscitation. Published 8 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →