Cardiac arrest & resuscitation
High versus low mean arterial pressure targets after out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials
Authors' conclusion
A high MAP target may reduce ICU stay and mechanical ventilation duration but did not demonstrate improvements in either mortality or favorable neurological recovery.
Study context
- Population
- Patients after out-of-hospital cardiac arrest (OHCA) resuscitation
- Participants
- 1,065 patients · 4 randomized controlled trials (RCTs)
- Comparison
- High vs low mean arterial pressure (MAP) target
- Outcome
- All-cause mortality and favorable neurological recovery
Methodological detailsprospectively registered protocol
- Prospectively registered protocol
Pooled result
As reported in the abstract
High MAP vs Low MAPRelative risk (95% CI)P value
All-cause mortality
1.07(0.91–1.27)
P = 0.4Favorable neurological recovery
1.02(0.93–1.13)
P = 0.68Further pooled results
| Outcome | MD (95 CI) | P value | |
|---|---|---|---|
| ICU stay duration | −0.78 (−1.54 to −0.02) | P = 0.04 | |
| Mechanical ventilation duration | −0.91 (−1.51 to −0.31) | P = 0.003 | |
| −2−101Difference (linear scale) |
Original publication
High versus low mean arterial pressure targets after out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials. J Crit Care. Published 27 July 2023. doi:10.
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