Fluid infusion prior to intubation or anesthesia: A meta-analysis of randomized controlled trials
Pooled result · Hypotensive eventsResult — go to the resultRelative risk 0.78 95% CI 0.66–0.92Authors' conclusion
Pre-induction rehydration can reduce the occurrence of hypotensive events, but only in pre-surgical patients, and does not decrease the use of vasoactive medications.
Study context
- Population
- Patients undergoing tracheal intubation or surgical procedures
- Participants
- 2,850 patients · 7 randomized controlled trials (RCTs)
- Comparison
- Pre-induction IV rehydration vs no rehydration
- Rehydrationn = 1,430
- Controln = 1,420reference
- Outcome
- Hypotensive events and use of vasoactive drugs after anaesthesia induction
Methodological detailsPRISMA, No evidence of publication bias on funnel plot
- PRISMA
- No evidence of publication bias on funnel plot
Pooled result
Hypotensive events
Relative risk
0.78
95% CI 0.66–0.92
P = 0.004
Rehydration vs Control
RR 0.78 (95% CI 0.66–0.92); P = 0.004
As reported in the abstract
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Hypotensive events, critically ill patients, rehydration before tracheal intubation (subgroup) | 0.99 (0.61–1.60) | P = 0.96 | |
| Use of vasoactive medicationsI2 = 23% | 0.96 (0.80–1.16) | P = 0.69 | |
| 0.512Relative risk (log scale) |
- Use of vasoactive medications: no heterogeneity (p = 0.26)
Original publication
Fluid infusion prior to intubation or anesthesia: A meta-analysis of randomized controlled trials. J Crit Care. Published 24 July 2024. doi:10.
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