Fluoroscopy-guided high-intensity focused ultrasound neurotomy of the lumbar zygapophyseal joints: a prospective, open-label study
Authors' conclusion
Fluoroscopy-guided HIFU neurotomy achieved clinical responses comparable with RFA, and there were no significant device-related or procedure-related AEs.
Study context
- Population
- Adults with lumbar zygapophyseal joint syndrome with prior positive response to a single diagnostic analgesic block or radiofrequency ablation (RFA)
- Participants
- 30 adults
- Outcome
- Individual responder rate (≥2-point reduction in pain NRS without increased opioid intake, or reduced opioid intake without increased pain)
- Follow-up
- 6 months
Methodological detailsopen-label, dual centre
- Open-label
- Dual centre
Main finding
As reported in the abstract
Individual responder rate · 180 days
Individual responder rate at 180 days
82.6%
Observational data: associations, not effects.
Secondary outcomes
Individual responder rate at earlier time points · 2, 7, 14, 30, 90 days
- 2 days
- 89.7%
- 7 days
- 89.7%
- 14 days
- 72.4%
- 30 days
- 82.1%
- 90 days
- 59.3%
Average pain NRS (baseline 7.1)
- Baseline
- 7.1
- 2 days (N=29)
- 3.0
- 7 days (N=29)
- 3.0
- 14 days (N=29)
- 3.1
- 30 days (N=28)
- 3.2
- 90 days (N=27)
- 4.3
- 180 days (N=23)
- 3.3
Safety
Procedure-related or device-related adverse events (AEs)
- All participants tolerated the procedure well with no significant side effects or complications
Original publication
Fluoroscopy-guided high-intensity focused ultrasound neurotomy of the lumbar zygapophyseal joints: a prospective, open-label study. Reg Anesth Pain Med. Published 5 April 2024. doi:10.
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