Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain
Authors' conclusion
These findings suggest a key protective role for the adaptive immune system in the development of chronic post-surgical pain.
Study context
- Population
- Individuals undergoing hysterectomy, mastectomy, abdominal, hernia, and knee surgery; mice after plantar incision and laparotomy5 surgery types
- Participants
- 1,350 individuals
- Comparison
- Rag1 null mutant vs wild-type mice after plantar incision and laparotomy
- Outcome
- Genetic risk of CPSP (GWAS meta-analysis: genome-wide significant SNP hits and SNP-based heritability)
Methodological detailspartitioned heritability, Rag1 null mutant mouse model, flow cytometry
- Partitioned heritability
- Rag1 null mutant mouse model
- Flow cytometry
Pooled result
As reported in the abstract
Genome-wide significant single-nucleotide polymorphism (SNP) hits
77
Loci
24
Genes
244
SNP-based narrow-sense heritability for chronic post-surgical pain (CPSP)
∼39%
Further pooled results
Allodynia in Rag1 null mutant mice · up to 42 days after surgery
- Exacerbated and prolonged allodynia in Rag1 null mutant mice, rescued by B-cell transfer
Immune cell recruitment (footpad, lymph nodes, dorsal root ganglia) · first 7 days after injury
- Recruitment patterns of B cells but not T cells differed significantly
Original publication
Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain. Br J Anaesth. Published 10 June 2024. doi:10.
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