Genome-wide association study on chronic postsurgical pain in the UK Biobank
Authors' conclusion
This study contributes new insights into the genetic factors associated with CPSP.
Study context
- Population
- UK Biobank individuals who had undergone different surgical procedures
- Participants
- 95,931 individuals
- Comparison
- Chronic postsurgical pain (CPSP) cases vs controls
- Casesn = 2,923
- Controlsn = 93,008reference
- Outcome
- Genetic variants associated with CPSP
Methodological detailscase-control analysis, ordinal analysis, meta-analysis with a published dataset
- Case-control analysis
- Ordinal analysis
- Meta-analysis with a published dataset
Pooled result
As reported in the abstract
Genome-wide association with CPSP (case-control analysis)
Loci within GLRA3 with genome-wide significant association (P<2.5×10-8)
1
Loci with suggestively significant associations (P<1×10-6)
9
Further pooled results
Ordinal analysis (3 groups by time of analgesics use)
- Aligned with case-control analysis; additional locus (rs140330443) reached genome-wide significance
Meta-analysis with recently published dataset (n=97,281)
- Single nucleotide polymorphism (SNP) rs17298280 in GLRA3 remained significant
- P = 2.19×10-9
Original publication
Genome-wide association study on chronic postsurgical pain in the UK Biobank. Br J Anaesth. Published 25 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →