Genome‐wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank
Authors' conclusion
This study provides preliminary evidence for genetic risk factors implicated in chronic postsurgical pain following abdominal surgery, particularly the PDE4D gene, which has been associated with pain in previous studies.
Study context
- Population
- UK Biobank patients who underwent abdominal surgery
- Participants
- 27,603 patients
- Outcome
- Single-nucleotide polymorphisms associated with chronic postsurgical pain development
Methodological detailssplit-half validation, expression validation in clinical samples
- Split-half validation
- Expression validation in clinical samples
Performance
As reported in the abstract
Locus reaching genome-wide significance (rs185545327)
1
Loci surpassing suggestive threshold (p < 1 × 10-6)
10
Loci with at least nominal significance in robustness analysis
8
Genes mapped from suggestive loci; 2 loci contained pain-related genes (SRPK2, PDE4D)
15
Further findings
PDE4D expression in clinical adhesion samples, pain vs no pain
- Detection rate and expression level of PDE4D modestly higher in patients with pain vs controls, marginally approaching statistical significance
Original publication
Genome‐wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank. Anaesthesia. Published 29 December 2024. doi:10.
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